Phenoxyethanol

    • Product Name: Phenoxyethanol
    • Chemical Name (IUPAC): 2-Phenoxyethan-1-ol
    • CAS No.: 122-99-6
    • Chemical Formula: C8H10O2
    • Form/Physical State: Liquid
    • Factroy Site: Binhai Economic and Technological Development Zone, Weifang City, Shandong Province
    • Price Inquiry: sales2@liwei-chem.com
    • Manufacturer: Shandong Haihua Group Co.,Ltd.
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    Specifications
    HS Code 761883
    Chemical Name Phenoxyethanol
    Cas Number 122-99-6
    Molecular Formula C8H10O2
    Molecular Weight 138.17 g/mol
    Appearance Colorless, oily liquid
    Odor Faint rose-like
    Boiling Point 247°C
    Melting Point −2°C
    Solubility In Water 1.2 g/100 mL (20°C)
    Density 1.10 g/cm3
    Refractive Index 1.535 (20°C)
    Flash Point 121°C
    Ph Value Neutral (approx. 7 when dissolved in water)
    Vapor Pressure 0.11 mmHg (20°C)
    Common Uses Preservative in cosmetics and pharmaceuticals

    As an accredited Phenoxyethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Phenoxyethanol is packaged in a 500 mL amber glass bottle with a secure screw cap and clear hazard labeling.
    Container Loading (20′ FCL) 20′ FCL container loading for Phenoxyethanol: typically 80-100 drums (200kg each), totaling about 16-20 metric tons per container.
    Shipping Phenoxyethanol is shipped in tightly sealed containers made of compatible materials, such as high-density polyethylene or stainless steel. It should be stored and transported in cool, dry, well-ventilated areas away from sources of ignition and strong oxidizers. Appropriate hazard labeling and documentation, including safety data sheets, are required during shipment.
    Storage Phenoxyethanol should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from direct sunlight, heat, and sources of ignition. Keep it away from strong oxidizers, acids, and bases. Avoid moisture exposure, and ensure containers are clearly labeled. Use proper personal protective equipment when handling to prevent skin and eye contact.
    Shelf Life Phenoxyethanol typically has a shelf life of 24 to 36 months when stored in a cool, dry, and tightly sealed container.
    Application of Phenoxyethanol

    Applications of Phenoxyethanol in Industrial Manufacturing

    We supply phenoxyethanol to large-scale industrial customers who require consistent microbiological protection and stable processing performance. Below, we detail core application fields where phenoxyethanol integrates into manufacturing lines, listing regulatory benchmarks, technical formulation guides, process entry points, and completed product profiles based directly on sector usage.

    1. Personal Care Preservation Systems

    Major companies in the personal care sector utilize phenoxyethanol primarily as an antimicrobial preservative. Its function is to prevent spoilage and contamination in emulsions, aqueous lotions, gels, and sunscreens. Regulatory frameworks for these goods demand high product safety and reliable shelf stability. Formulators rely on its solubility profile and compatibility with other preservative actives. Quality control teams conduct challenge testing to verify preservative adequacy in finished batches.

    Industry compliance standards

    • EU Cosmetics Regulation (EC) No 1223/2009 (Annex V, entry 29)
    • US FDA 21 CFR Parts 700.3 & 720.4
    • ASEAN Cosmetic Directive
    • ISO 11930 Microbiological Evaluation of Cosmetic Preservation

    Typical usage ratio

    • 0.4% – 1.0% by weight, adjusted based on water activity, pH, and product matrix composition

    Downstream process integration

    • Added during the cool-down phase post-emulsification, after bulk mixing of phase components
    • Dosing via in-line metering or batch addition tanks, maintained below 40°C to prevent volatility loss

    Final product types

    • Facial creams and lotions
    • Body wash and liquid soaps
    • Sunscreen emulsions
    • Wet wipes and leave-on skincare treatments

    2. Pharmaceutical Topical Preparations

    Pharmaceutical manufacturers deploy phenoxyethanol in antimicrobial systems for topical ointments, gels, and creams. This raw material suppresses bacterial and fungal growth within pharmaceuticals, provided strict limits on content and purity. Pharmacopoeial standards distinguish permissible grades and detail impurity thresholds. GMP-compliant facilities incorporate routine assays and endotoxin testing during process validation and lot release.

    Industry compliance standards

    • European Pharmacopoeia (Ph. Eur.) monograph 01/2008:1511
    • US Pharmacopeia (USP-NF)
    • Japanese Pharmacopoeia (JP)
    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients

    Typical usage ratio

    • 0.5% – 1.0% in finished dosage forms; reduced to 0.3% when co-preserved with other antimicrobials

    Downstream process integration

    • Introduced into semi-solid bulk following actives dissolution, with controlled mixing to ensure homogeneity
    • Integrated before terminal sterile filtration if required

    Final product types

    • Medicated creams and gels
    • Topical antiseptic solutions
    • Corticosteroid ointments
    • Dermatological compounded bases

    3. Industrial Water-Based Paints and Coatings

    Paint and coating producers rely on phenoxyethanol as a preservative to safeguard waterborne formulations during storage and application. It inhibits bacterial growth in high-water-content dispersions and supports pigment dispersion stability. Compliance focuses on responsible handling and environmental safety standards within plant operations.

    Industry compliance standards

    • REACH Registration (EC) No. 1907/2006
    • US EPA TSCA Inventory
    • Directive 2004/42/EC (VOC Directives for Decorative Paints)
    • ISO 11998 for Wet Scrub Resistance Testing

    Typical usage ratio

    • 0.2% – 0.7%, optimized based on water content, pigment load, and expected open time on site

    Downstream process integration

    • Metered into the water phase during pigment dispersion stage, or into let-down during final adjustment phase
    • Batch records maintain detailed preservative addition logs for QC traceability

    Final product types

    • Interior wall paints
    • Exterior façade emulsions
    • Waterborne varnishes
    • Architectural primer coatings

    4. Inks and Printing Industry

    Ink manufacturers use phenoxyethanol to extend shelf life and maintain microbe-free ink concentrates, especially in water-based flexographic and gravure printing inks. The compound reduces risk of microbiological spoilage and helps keep viscosity steady over time, supporting large printing runs and minimizing downtime.

    Industry compliance standards

    • EuPIA Exclusion Policy for Printing Inks and Related Products
    • Swiss Ordinance on Materials and Articles in Contact with Food (817.023.21, applicable for food packaging inks)
    • ISO 2846 and ISO 2834 for Ink Color and Printability Testing
    • GMP for Printing Inks (EC) No 2023/2006

    Typical usage ratio

    • 0.3% – 0.6%, adjusted according to ink binder system and pigment compatibility

    Downstream process integration

    • Added in the final formulation stage before filtration and packaging
    • Batched with dispersants and wetting agents for uniform distribution

    Final product types

    • Water-based flexographic inks
    • Gravure printing inks
    • Digital inkjet concentrates
    • Screen printing pastes

    5. Household and Institutional Cleaning Products

    Major cleaning product manufacturers incorporate phenoxyethanol to inhibit microbial growth in detergent concentrates, all-purpose cleaners, and surface disinfectant solutions. Performance depends on pH tolerance and solubility with surfactants and fragrances. Manufacturers monitor preservative stability during accelerated aging to meet in-market stability claims.

    Industry compliance standards

    • US EPA Safer Choice Ingredient List
    • BPR (Biocidal Products Regulation) (EU) No 528/2012
    • IFRA Standards for Home Care
    • Regulation (EC) No 648/2004 on Detergents

    Typical usage ratio

    • 0.2% – 0.5% depending on water activity, surfactant compatibility, and pH (stable up to pH 9)

    Downstream process integration

    • Added to the liquid blend tank immediately after surfactant and builder dissolution
    • Recirculated for uniform distribution prior to fragrance addition

    Final product types

    • Multi-surface liquid cleaners
    • Glass and hard surface sprays
    • Laundry pre-wash solutions
    • All-purpose disinfecting concentrates

    6. Industrial Adhesives and Sealants

    Manufacturers of water-based adhesives and latex sealants integrate phenoxyethanol as a preservative to prevent microbial spoilage in storage and after application. This material is particularly favored in non-solvent, high-viscosity formulations where fungal and bacterial contamination could undermine bond strength or cause product gassing.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006
    • ASTM D4498 Standard for Polymeric Emulsions
    • ISO 9001:2015 for Quality Management in Chemical Manufacturing
    • US FDA 21 CFR 175.105 (Adhesives in food packaging, indirect contact)

    Typical usage ratio

    • 0.15% – 0.45% depending on open pail storage time and formulation water content

    Downstream process integration

    • Incorporated to the water phase prior to final emulsification or high-shear mixing
    • QC samples withdrawn post-mixing for microbial count validation

    Final product types

    • Carpet adhesives
    • Construction latex sealants
    • Water-borne assembly adhesives
    • Packaging glue emulsions
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    Certification & Compliance
    More Introduction

    Phenoxyethanol: A Manufacturer’s Perspective on a Versatile Chemical Ingredient

    Phenoxyethanol and What Makes It Stand Out

    Producing phenoxyethanol has taught our team a lot about balancing safety, purity, and cost-effectiveness. As a glycol ether, our phenoxyethanol features an aromatic ring with an ethoxy group, which brings together properties of both alcohols and ethers. This chemical structure gives the product its profile: clear liquid, faint odor, stable under typical storage and processing conditions. Customers depend on the reliability and traceability that come with manufacturing at scale, which means our focus stays fixed on delivering a consistent and high-purity product.

    The main model we produce is ethylene glycol monophenyl ether (C8H10O2), commonly known by its full IUPAC name. Our large-batch processes yield a specification with minimum purity levels of 99.5%. We routinely check for residual solvents, heavy metals, and water content to ensure that every drum or IBC that leaves the plant matches both industry standards and the demands of our long-term clients.

    Experience, Safety, and Quality Control

    Every stage of our process matters. Temperatures, pH levels, and reaction times call for careful monitoring. Deviations can introduce impurities or lower yields, affecting usability in downstream applications. It’s not enough to meet a broad description of what phenoxyethanol should be; each order gets tight internal QC testing, verified by gas chromatography and microbe screenings.

    Global regulatory changes—especially in the cosmetics and pharmaceutical fields—have put more focus on the origins and process controls of raw materials. Certificates of Analysis and batch traceability form a bedrock of trust. Years ago, a few clients experienced issues using imported batches with less-stringent QC. Those cases drove changes in our traceability systems and increased the depth of analytical data we now offer with each shipment. Consistent data, transparent sourcing, and open problem-solving matter just as much as molecular purity.

    Applications Across Industries

    Manufacturers and formulators look for phenoxyethanol because it provides much-needed microbial protection in cosmetic products. Parabens have fallen out of favor with many brands. Our phenoxyethanol fills that gap because it covers a broad range of bacteria and yeasts, allowing for lower concentrations to do the work of older, more heavily-used preservatives. Customers in the skincare, haircare, and personal care industries often need a preservative that does not change texture, scent, or color in finished goods.

    Other regular users include ink and paint makers. Inkjet inks require stable solvents that do not evaporate too fast. Phenoxyethanol helps slow that process, which improves jetting and color consistency. In coatings and paints, it distributes pigment and improves gloss retention. Many of our clients in the specialty ink market buy modified grades, tailored to their precise viscosity and volatility requirements.

    Pharmaceutical producers value the low toxicity, mild scent, and regulatory approval in several key markets. For oral and topical uses, every ingredient receives intense scrutiny: contaminants or excessive moisture cannot slip through the net. We maintain a dedicated GMP production line for pharma customers, with isolation from industrial material flows.

    Laboratory formulators and scientists frequently rely on our material as a fixative agent, solvent for resins, and a bactericidal agent in cell culture media. During urgent research windows (such as public health events), reliable domestic sourcing can prevent slowdowns in trials and validation studies.

    What Sets Our Phenoxyethanol Apart

    Not all phenoxyethanol matches the same grade or origin. Some factories cut corners on the precursor phenol or employ lower-grade ethylene oxide. These changes can raise byproduct content—like dioxane or residual phenol—which in turn complicates product labels and increases rejection rates further along the value chain. Shortcuts rarely pay off; they may even drive risk of recall for brands that need to maintain regulatory compliance in global sales.

    Our difference comes down to source selection and process controls. The main raw materials, phenol and ethylene oxide, reach us from audited suppliers with dependable quality records. We balance production temperature and reaction rate, reducing formation of unwanted ethers or byproducts. Our reactors use stainless internals, not just for corrosion resistance, but to keep cross-contamination at bay for specialty applications.

    Distributors sometimes push for price cuts by accepting low-spec batches, but our plant leaders have learned the hard way: testing and re-processing a rejected container proves costlier than just getting it right on the first pass. Traceable, consistent batches build trust—especially when a single recall can wipe out years of client loyalty.

    Direct clients often have deeper insight into process needs: a printer manufacturer may specify cloudiness ratings, a skincare chemist might demand low odor. Some ask us to rerun analytical samples to spot trace aldehydes or nitrosamines—impurities that might slip through older methods. Responding to these asks means partnering with our lab teams, re-examining historical data, and sometimes investing in new analytical equipment or refining downstream processing.

    Comparing Phenoxyethanol to Alternative Preservatives and Solvents

    Many formulation chemists face the preservative challenge: their value chain increasingly asks for broad-spectrum products that don’t cause allergic reactions or controversial labeling. Compared to older preservatives (such as formaldehyde donors, parabens, or isothiazolinones), phenoxyethanol provides a broad activity window at moderate use levels. It manages to keep microbial counts down without the irritation or sensitization that some customers associate with the alternatives.

    In perfume and fragrance applications, benzyl alcohol sometimes shows up on ingredient lists, yet it occasionally triggers allergic skin responses. Phenoxyethanol offers similar solvency and volatility but does it without common fragrance allergen flags. It works as a fixative in perfumes, allowing for sustained scent delivery and uniform evaporation rates. More brands have migrated to phenoxyethanol after consumer groups raised alarms about suspected endocrine disruption in other ingredients.

    For pharmaceuticals, some turn to propylene glycol and ethanol as solvents. Both carry their own safety profiles. Ethanol evaporates quickly and can dry out the skin or mucous membranes. Propylene glycol, though generally recognized as safe, sometimes gets flagged for potential irritation at higher concentrations. Our pure phenoxyethanol offers a gentle alternative for oral syrups, topical gels, and ointments, blending well with active compounds and excipients.

    Preservative blends lean on phenoxyethanol’s versatile profile. Many globally distributed products combine phenoxyethanol with ethylhexylglycerin or potassium sorbate, lowering total concentrations while covering a broader microbial spectrum. In our experience, feedback from brand owners makes clear: the fewer clickbait headlines tied to a preservative, the easier it becomes to maintain market share.

    Technical Details and Real-World Production Lessons

    On the plant floor, phenoxyethanol synthesis requires a measured reaction between phenol and ethylene oxide. Side reactions can take yield down, raise impurity content, or saddle us with costly waste treatment. Training operators on batch consistency, not just throughput, pays off. Every change in feedstock or conditions—water content in the ethylene oxide, cooling rates, impurity levels—can influence downstream usability in preservative or solvent roles.

    We place tight attention on metallic ions in the product, which can act as catalysts for further breakdown or color changes in cosmetic use. Every time a customer reports a shift in final product tone, our team looks for batch records and cross-references with those ionic levels. Years of shared data with partner labs and downstream users helps us catch anomalies before they become problems on retail shelves.

    Water content matters for some end users more than others. In high purity pharma applications, excess moisture can delay blending or reduce long-term stability. By maintaining closed-system transfers and dry storage, we keep water content low. This is especially critical for cell media and high-grade excipients, where small changes can impact gel or solution behavior.

    Our internal QA processes do more than tick off specification boxes. We stress-test random samples under accelerated storage conditions: heat, light, and humidity exposure show which samples hold up over time. This provides evidence back to formulators who want to know how our material will behave; data from storage at 40°C, for instance, helps clients in tropical climates avoid shelf-life surprises.

    Industry Shifts and Market Feedback

    Over the past decade, the market for phenoxyethanol has seen steady changes. Rising demand for “clean label” cosmetics and personal care lines shaped much of our batch development work. Many indie brands and multinational customers press us for extra details—not just purity, but confirmation of non-GMO source, origin disclosure, and allergen review. These aren’t abstract requests: every year, more client audits scrutinize supply chain transparency and sustainability efforts.

    Increased focus on microplastics and downstream aquatic safety affected which auxiliary agents we continued using in production and bottling. Regulatory changes in geopolitical blocs—EU, North America, East Asia—require close monitoring. EU Cosmetic Regulation caps max allowed phenoxyethanol in finished formulations; our clients rely on consistent grade and accurate technical data so their products meet these complex demands.

    The COVID-19 years put new pressure on producers to keep supply moving while fielding unpredictable logistics. With rising freight rates and sometimes unstable delivery windows, local clients began splitting orders—asking for smaller batches more frequently, rather than single large bulk shipments. We rebalanced storage and QA rotation schedules to keep lead times tight while still hitting the same tight specs.

    Common Misconceptions and Practical Advice

    It’s easy to find online criticism of common preservatives. These conversations matter, but a lot of what we read misses the context of ingredient sourcing, regulatory review, and production reality. Phenoxyethanol, when made to a high grade, offers broad-spectrum protection at safe concentrations backed by decades of clinical and toxicological data. The few reported allergic reactions trend far below those seen with many synthetic or natural alternatives.

    Marketers sometimes pitch “preservative free” as a clear benefit. Yet even so-called “natural” brands quietly include phenoxyethanol derivatives because natural extracts alone rarely provide sufficient protection for shelf lives over 18 months. Without the benefit of honest conversations, brands can end up chasing supply from unofficial sources, risking higher rates of batch spoilage or contamination recalls.

    The best results for finished product safety and shelf life come from open dialogue between manufacturers and ingredient suppliers. For example, we often spot issues early on by reviewing a customer’s base formulas: pH, viscosity, or desired usage rates can push a product just outside the efficacy window. Honest conversations with formulating chemists help everyone save on troubleshooting runs and wasted batches later.

    Sustainability Questions and the Road Ahead

    Our industry faces more pressure to reduce waste at every stage of production and distribution. Phenoxyethanol has a lighter waste profile than some older preservatives; distillation and byproduct streams can be managed efficiently, without halogenated effluent or persistent environmental hazards. Our facility reclaims heat for secondary processes and reduced solvent loss; we’re working on catalyst recovery and closed-system transfer improvements next.

    Some clients ask detailed questions on carbon footprint; others focus on fair labor sourcing for starting materials. As questions grow more complex—extending beyond chemical purity and formulation data—producers have to adapt. There’s no single answer, but investing in better traceability, raw material audits, and open-book production justifies itself over time. Our clients regularly ask for support in Life Cycle Assessment (LCA) and sustainability audits. Through careful record keeping and process improvements, we provide the data needed for eco-certification and compliance with corporate responsibility targets.

    To address future challenges, we share production data with industry groups working toward greener processes. This includes improving the handling and recovery of phenol and ethylene oxide as starting materials. Over time, a shift toward biobased feedstocks could further improve sustainability metrics. Piloting those methods takes real investment, but the early returns show promise—not just for the environment, but for customers who want their brands to embody forward-looking values.

    The Value of Relationship and Reputation

    Plant managers and chemists alike understand that small inconsistencies in phenoxyethanol could build up as major headaches for our partners. Surprises don’t help either side. Years of running this business confirms that the best manufacturers treat every client query—about safety, origins, or test data—with respect. No two production runs are exactly the same, but showing clear records, open communication, and willingness to improve speaks more loudly than any long-winded brochures.

    Many of our long-term relationships were forged by working together through changing regulatory rules, evolving consumer trends, and the occasional raw material shortfall. Some clients buy only a few drums a year yet push us with exacting specs or complex questions. Others run full-scale multinational production streams and want reassurance for every upstream and downstream supplier they engage. Each adds a line to the story of how phenoxyethanol’s capabilities developed and how end users benefit from a consistently high-quality product.

    From batch labeling to sustainability audits, from the first sample analysis to a full-scale supply contract, every part of the process reflects the lessons we’ve learned as a direct manufacturer. In the end, it’s not just about a product in a drum or an IBC—it’s about trust, shared value, and the responsibilities of quality at scale.