Non-ionic Surfactant (Polysorbate 20) TWEEN 20 (HMT-20)

    • Product Name: Non-ionic Surfactant (Polysorbate 20) TWEEN 20 (HMT-20)
    • Chemical Name (IUPAC): Polyoxyethylene (20) sorbitan monolaurate
    • CAS No.: 9005-64-5
    • Chemical Formula: C58H114O26
    • Form/Physical State: Liquid
    • Factroy Site: Binhai Economic and Technological Development Zone, Weifang City, Shandong Province
    • Price Inquiry: sales2@liwei-chem.com
    • Manufacturer: Shandong Haihua Group Co.,Ltd.
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    Specifications
    HS Code 380293
    Chemical Name Polysorbate 20
    Common Name Tween 20
    Type Non-ionic surfactant
    Appearance Clear to slightly yellow viscous liquid
    Molecular Formula C58H114O26
    Molecular Weight 1227.54 g/mol
    Hydrophilic Lipophilic Balance Hlb 16.7
    Solubility Soluble in water and ethanol
    Boiling Point >100°C
    Flash Point >100°C
    Ph Range 5.0 - 7.0 (5% solution in water)
    Odor Characteristic, mild
    Density 1.09 g/cm³ (at 25°C)
    Cas Number 9005-64-5
    Primary Use Emulsifier and solubilizer in pharmaceuticals, cosmetics, and food

    As an accredited Non-ionic Surfactant (Polysorbate 20) TWEEN 20 (HMT-20) factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing TWEEN 20 (HMT-20) Non-ionic Surfactant, 1 Liter, is packaged in a sturdy, white, sealed HDPE bottle with label.
    Container Loading (20′ FCL) 20′ FCL contains 16,000 kg of Non-ionic Surfactant Polysorbate 20 (TWEEN 20), packed in 160 x 200kg HDPE drums.
    Shipping **Shipping Description:** Non-ionic Surfactant (Polysorbate 20) TWEEN 20 (HMT-20) is shipped in sealed, leak-proof HDPE containers or drums. Store and transport upright, protected from moisture, direct sunlight, and extreme temperatures. Complies with non-hazardous chemical transport regulations. Ensure all containers are clearly labeled and handled with standard safety precautions during shipping.
    Storage Non-ionic Surfactant (Polysorbate 20) TWEEN 20 (HMT-20) should be stored in a tightly sealed container in a cool, dry, well-ventilated area, away from direct sunlight, heat sources, and incompatible materials (strong oxidizers). Protect from moisture and contamination. Store at room temperature, and avoid freezing. Always ensure containers are labeled properly and handled according to safety guidelines.
    Shelf Life Shelf life of Non-ionic Surfactant (Polysorbate 20) TWEEN 20 (HMT-20) is typically 24 months when stored properly, unopened.
    Application of Non-ionic Surfactant (Polysorbate 20) TWEEN 20 (HMT-20)

    Applications of Non-ionic Surfactant (Polysorbate 20) TWEEN 20 (HMT-20) in Industrial Manufacturing

    We supply high-purity non-ionic surfactant Polysorbate 20 (TWEEN 20, HMT-20) to a range of industrial processors, focusing on sectors requiring effective emulsification, solubilization, and dispersion. Below, we outline verified application scenarios, each reflecting the direct integration and compliance requirements within real-world downstream operations.

    1. Pharmaceutical Injectable Formulations

    Polysorbate 20 serves as a solubilizing agent and stabilizer in parenteral drug manufacturing, specifically for protein and peptide-based injectables where it prevents aggregation and surface adsorption during both fill-finish and storage. Its addition ensures uniform dispersion of active pharmaceutical ingredients (APIs), supporting dose consistency throughout the batch process and shelf life.

    Industry compliance standards

    • United States Pharmacopeia (USP-NF)
    • European Pharmacopoeia (Ph. Eur.)
    • Japanese Pharmacopoeia (JP)
    • Good Manufacturing Practice (ICH Q7, EU GMP Annex 1)

    Typical usage ratio

    • 0.005%–0.1% w/v, based on total solution; adjusted upward in higher-protein formulations or for increased solubility requirements

    Downstream process integration

    • Added after buffer preparation and before final filtration, ensuring complete dissolution before API addition; typically pre-filtered to remove particulates prior to sterile fill

    Final product types

    • Monoclonal antibody injections
    • Peptide hormone injectables
    • Cytokine and vaccine vials
    • Biologic drug prefilled syringes

    2. Food Flavor Emulsions and Beverage Formulation

    Within food processing, Polysorbate 20 acts as an emulsifier in clouding agents and beverage flavor oils, enabling the formation of stable oil-in-water dispersions for clear or cloudy soft drinks. Its hyper-purified grade ensures safety and clarity in applications demanding transparent or homogeneously turbid appearance without phase separation during shelf life and logistics.

    Industry compliance standards

    • FAO/WHO JECFA Food Additive Specification (INS No. 432)
    • US FDA 21 CFR 172.840 (Food Additive Status List)
    • GB 2760—Chinese National Food Safety Standard for Food Additives
    • ISO 22000 Food Safety Management System

    Typical usage ratio

    • 0.01%–0.05% w/w relative to the beverage base; optimized according to emulsion oil content and clarity requirements

    Downstream process integration

    • Dispersed into aqueous phase under high-shear mixing before the introduction of essential oils or colorants; forms a fine droplet microemulsion further stabilized by homogenization

    Final product types

    • Citrus-flavored soft drinks
    • Carbonated beverage concentrates
    • Non-alcoholic cocktail mixers
    • Emulsion-based syrups

    3. Industrial Enzyme Formulation

    Major enzyme producers incorporate Polysorbate 20 to enhance enzyme concentrate stability during granulation, spray drying, or as part of liquid enzyme solutions for detergents and processing aids. Its surface activity minimizes enzyme denaturation caused by interfacial stress during downstream manufacturing or product reconstitution by end-users.

    Industry compliance standards

    • OECD Guidelines for the Testing of Chemicals (Biodegradability)
    • Food Chemicals Codex (when used for food processing enzymes)
    • Current Good Manufacturing Practice (cGMP) for enzyme production (21 CFR Part 117)
    • EU REACH Registration (where applicable to usage volumes)

    Typical usage ratio

    • 0.01%–0.2% w/w, based on total enzyme formulation mass; adjusted based on enzyme type and stability target

    Downstream process integration

    • Blended into enzyme solutions prior to spray drying or granulation; in liquids, introduced post-fermentation and prior to bulk filling to prevent surface denaturation

    Final product types

    • Granular protease or lipase for detergents
    • Liquid cellulase or amylase concentrates
    • Feed enzyme premixes
    • Textile processing enzyme blends

    4. Personal Care and Cosmetic Emulsions

    Formulators in cosmetic manufacturing utilize Polysorbate 20 to emulsify fragrance oils and essential oils in aqueous personal care products, providing clarity and stability to transparent facial and body cleansers, as well as gentle makeup removers. Its non-ionic nature supports compatibility with anionic and amphoteric surfactants in multi-phase skin care and hair care systems.

    Industry compliance standards

    • Cosmetic Ingredient Review (CIR) Safety Assessment
    • EU Regulation (EC) No 1223/2009 (Cosmetics Regulation)
    • ISO 22716 Cosmetic GMP
    • US FDA Voluntary Cosmetic Registration Program (VCRP)

    Typical usage ratio

    • 0.05%–1.0% w/w, depending on oil load and desired transparency; higher concentrations for full solubilization of high-fragrance-load systems

    Downstream process integration

    • Added during aqueous phase preparation before introduction of perfume or essential oils; homogenized into base under moderate agitation to avoid excessive foam

    Final product types

    • Micellar water makeup removers
    • Clear liquid facial cleansers
    • Mild baby shampoos
    • Room and linen sprays

    5. In Vitro Diagnostic (IVD) Reagents

    Manufacturers of IVD kits and clinical diagnostic reagents apply Polysorbate 20 as a stabilizing and anti-adsorption agent in enzyme-linked immunosorbent assays (ELISAs) and buffer systems. Its inclusion ensures consistency in optical readings and reduces nonspecific binding in high-sensitivity immunodiagnostic applications, enhancing batch reliability for end users analyzing clinical samples.

    Industry compliance standards

    • ISO 13485 Medical Devices – Quality Management
    • US FDA 21 CFR Part 820 (Quality System Regulation for medical devices and diagnostics)
    • IVD Directive 98/79/EC (EU)
    • CLSI GP44-A4 (Procedures for Preparation and Storage of IVD Reagents)

    Typical usage ratio

    • 0.01%–0.2% w/v, based on reagent or buffer total volume; adjusted to minimize background and maximize specific signal

    Downstream process integration

    • Incorporated into wash buffers, conjugate stabilizers, or blocking solutions during the blending and filtration of liquid reagents

    Final product types

    • ELISA kit liquids and washes
    • Clinical immunoassay reagents
    • Calibrator and dilution buffers
    • Microplate wash solutions

    6. Tissue and Cell Culture Media Manufacturing

    Bioprocessing laboratories and commercial cell culture media mixers depend on Polysorbate 20 for enhancement of nutrient solubility and minimization of surface denaturation in serum-free or protein-enhanced growth media. Its application supports consistent cell viability, particularly during media sterilization and storage, where protein stabilization is critical for reproducible downstream bioprocessing.

    Industry compliance standards

    • US Pharmacopeia Chapter <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products
    • ISO 9001/ISO 13485 (for cell culture reagents manufacturing)
    • European Pharmacopoeia for Medium Components
    • Guidance for Industry: CGT (FDA)

    Typical usage ratio

    • 0.002%–0.02% w/v, adjusted according to protein content and desired protection against aggregation during heat sterilization

    Downstream process integration

    • Introduced into basal media during component blending, prior to sterile filtration or autoclaving, ensuring full dissolution and interaction with sensitive media ingredients

    Final product types

    • Serum-free cell culture media
    • Protein-supplemented growth media
    • Stem cell cultivation media
    • Cell therapy manufacturing process liquids
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    Competitive Non-ionic Surfactant (Polysorbate 20) TWEEN 20 (HMT-20) prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Non-ionic Surfactant Polysorbate 20 (TWEEN 20 HMT-20): Our Practical Experience and Value to Formulators

    What We’ve Learned on the Production Line

    Every workday in our plant involves more than meeting a set of numbers and batch targets. Our team has watched Polysorbate 20—often recognized as TWEEN 20 or under our own label, HMT-20—become a reliable staple across many industries. We have mixed, filtered, and quality-checked thousands of tons of this non-ionic surfactant over the years. This daily practice gives us a ground-level perspective on what sets it apart and what questions most clients ask before putting HMT-20 to work in their own operations.

    Why Polysorbate 20?

    Surfactants hold a special place in manufacturing because they don’t just help make something—they often make it possible. The core of Polysorbate 20 comes from the ethoxylation of sorbitan monolaurate. What we notice at the plant is the steadiness of its performance under demanding setups. The product’s clear, light yellow liquid form pours smoothly and blends cleanly, both in mixing tanks and smaller process vessels. Customers consistently remark on its low odor and the ease with which it dilutes, not just in water but in a wide range of organic solvents.

    Our own batches run at a purity that sees high acceptance rates from the cosmetics and food sectors. Industrial users, from metalworking fluid formulators to paint technicians, notice how our HMT-20 holds up to elevated shear and temperature cycles without throwing off separation or unwanted foaming.

    Specification and Consistency—Not Just Numbers

    Quality isn’t just paperwork. In our quality control lab, we keep polysorbate 20’s hydrophile-lipophile balance (HLB) at 16.7—a value that directly relates to its solid wetting and solubilization ability for oils in water-based systems. Our viscosity checks never slip into extremes so that bulk users avoid pump clogs and dosing mishaps. The pH range we maintain allows broad use without corrosion concerns or need for extra buffering chemistry.

    We track every batch for water-soluble impurity limits because users in personal care—like shampoo or lotion makers—need peace of mind about product safety and compliance. Food component suppliers rely on us for lab-verified data and traceability, which becomes essential when products cross borders or undergo third-party audits.

    How Our Clients Use HMT-20

    Personal Care and Cosmetics

    Labs and brands working on shampoos, cleansers, and creams favor HMT-20 for its mildness. It blends essential oils, active ingredients, and fragrances with water. Many R&D chemists point out that Polysorbate 20 avoids the skin irritation risk that can come from harsher surfactants, making it a go-to ingredient in children’s products and sensitive skin formulas. Its ability to hold cloudless, stable emulsions cuts down on batch rework and troubleshooting time.

    Food Applications

    Polysorbate 20 appears on food labels as an emulsifier and solubilizer. Its main role is to keep flavors, colors, and vitamins dispersed in beverages, sauces, and syrups. Our food-grade production takes special care to avoid cross-contamination, and our documentation has supported ingredient compliance checks across several continents. Chefs and food technologists report batch-to-batch consistency even under cold storage or mild pasteurization conditions.

    Pharmaceutical and Healthcare

    We see demand in the compounding of oral liquids and topical solutions. The pharmaceutical sector asks us for ultra-low residue content—a standard we track right from the start of every batch. Researchers use TWEEN 20 in laboratory buffers and cell culture work, specifically because it avoids cytotoxicity at necessary working concentrations. Its low reactivity means stability in the presence of a wide variety of actives, without triggering unwanted precipitation or loss of bioactivity.

    Industrial and Technical

    TWEEN 20 solves critical processing hurdles in metalworking, ink, and textile plants. Maintenance teams have less cleanup because our non-ionic product cleans without leaving a soap scum. Textile finishing operators use it for its anti-static and wet-out properties, helping fabrics catch dyes more evenly. Industrial cleaning product formulators use Polysorbate 20 for its excellent grease-cutting ability at relatively low concentrations, cutting raw material costs without hurting performance.

    Seeing the Differences—HMT-20 Compared With Other Surfactants

    Many surfactants can look similar in a spec sheet, but on the plant floor or in a lab tank, details matter. Sourcing managers weighing Polysorbate 20 against options like polysorbate 80 (TWEEN 80), sorbitan esters, or ethoxylated alcohols are often focused on risk—whether that’s skin sensitivity, stability, or raw material cost.

    Polysorbate 20 falls at the mild end of the spectrum. Its laurate base (compared to the oleate in polysorbate 80) means smaller molecular size and lower tendency to thicken solutions. If a formulator needs to solubilize delicate fragrances with minimal viscosity impact, HMT-20 is the better bet. For applications needing higher emulsification of heavy oils, polysorbate 80 wins but with a different skin compatibility trade-off.

    Compared to simple non-ionic surfactants like ethoxylated alcohols, TWEEN 20 shines in high-electrolyte solutions. Detergent makers can avoid cloudiness and keep formulas transparent at higher salt content, supporting both visual appeal and performance.

    Teams working with anionic or cationic surfactants sometimes need a neutral, non-reactive partner in their blends; HMT-20 fits because it doesn’t disrupt the charge balance in most systems. Further, it keeps foaming at lower, more predictable levels, suiting rinse-off products and high-shear processing.

    Our Approach to Manufacture—Accuracy, Safety, and Transparency

    To produce polysorbate 20 that operates worry-free across personal care, food, industrial, and laboratory platforms, we can’t rely on a single solution or shortcut. The starting materials—sorbitan monolaurate and ethylene oxide—get checked for purity and absence of byproducts before we greenlight them into a mixer. Each batch passes COA requirements for appearance, acid value, saponification value, water content, and peroxide levels.

    Workers on our lines use hard lessons from years of spills and unexpected pH shifts to keep processes tight and safe. Our plant’s closed-dosing systems and real-time spectrographic analytics mean fewer off-spec results and fewer waste drums. After every run, we review logs not just for compliance but for potential improvement—every repeat customer expects that level of diligence, especially in a world moving toward traceability and lower environmental impact.

    Sustainability—Toward a Cleaner Cycle

    Over time, we’ve noticed more clients asking about renewable sourcing and waste minimization around surfactants. In answer, we have shifted sourcing toward suppliers who offer vegetable-derived, certified palm-free raw materials, whenever possible. Our commitment isn’t just a selling point for supply chain managers; it matters to our own team, tasked with reducing our plant’s environmental footprint.

    We recover heat from ethoxylation steps, use in-house water recycling for cleaning, and are working toward ISO certifications around both quality and environmental management. Partners in personal care and food export markets regularly audit us to ensure our processes stand up to global scrutiny. This bridges compliance with actual results—less raw material waste and lower chemical run-off.

    Batches That Build Trust

    Any seasoned formulator or manufacturing manager knows that one off-batch can mean thousands lost—not only in production delays but in regulatory headaches and damaged reputations. Our own product managers spend time with end users, fielding technical questions and sharing sample performance data from applications ranging from full-scale mixer trials to hand-blended prototypes.

    Quality managers want to see more than a Certificate of Analysis; they want references, real production records, and access to technical support. Our technical service team tracks the performance of HMT-20 in customer lines to catch any incompatibility or unexpected outcome early. This feedback pipeline runs all the way back to our production engineers, who constantly push for more reliable and traceable chemistries.

    Looking Ahead—What HMT-20 Means in a Changing Industry

    Polysorbate 20’s strengths match shifts in regulatory and consumer expectations. The global move toward cleaner label ingredients and allergen control puts immense focus on starter materials, cross-contamination, and batch documentation. Because our team includes both plant and quality system veterans, we don’t just talk through audit points; we build systems to meet them.

    Clients in cosmetics and food look for globally accepted, widely registered excipients. That focus means we keep up with changing requirements from agencies in the US, EU, and Asia. As ingredient requirements get stricter, our batch history, allergen-free handling lines, and cleanroom sampling stand out in crowded ingredient lists. We hear more requests for non-GMO, vegan, or allergen-free documentation. Each request feeds into future product development and raw material prioritization.

    Industrial buyers keep chasing dependable, cost-efficient input chemicals. Short supply, fluctuating shipping costs, or unsteady batch-to-batch results can crush a year’s margins. Our local teams work around the clock to buffer customers from global price surges, whether through smarter stockpiling or flexible packaging.

    Challenges and Practical Solutions

    Small changes in raw material purity or storage conditions can shift the final polysorbate 20. High-water content during storage can trigger microbial growth or hydrolysis, risking both shelf life and regulatory compliance. That’s why we monitor each drum before shipping, make sure closures are tight, and supply guidance for warehouse managers to avoid bright sunlight and high humidity.

    Incompatibility with certain actives—especially in food or topical pharmaceuticals—sometimes pops up as haze, color drift, or unexpected odor. We encourage extended real-world stability testing and provide smaller pre-ship samples so formulators can troubleshoot before scaling up.

    Environmental discharge rules keep tightening, especially for non-biodegradable surfactants. Our R&D has invested in process tweaks and post-use water treatment options to lower risk. For users worried about environmental health, our technical team shares breakdown profiles and recommends configuration changes—like lower-use rates or alternate discharge controls—proven to work in the field.

    Our Experience in Scale-Up and Support

    From bench work to pilot runs and full container shipments, each phase brings its own worries. Changing tank size, mixing speed, or temperature can throw off results, so our team often joins scale-up meetings with clients, whether in person or through live data sharing. We’ve seen time and again that sharing hands-on troubleshooting tips saves hours or days on the back end.

    Shipping large volumes means containers crossing regions with varying climate swings. We help logistics teams choose packing that prevents crystallization or separation—insulated drums, liners, or even tankers with in-transit heating when necessary. Our warehouse logs document every shipment for chain-of-custody and traceability, so global buyers can keep compliant as rules evolve.

    The Human Side—How Relationships Shape Performance

    Behind every tank or drum of HMT-20 is a team that answers to both regulations and the real-world needs of chemists, engineers, and operators. The most durable business comes from listening to feedback—good or bad—and training everyone, from forklift operators to senior chemists, to notice problems early. We run regular workshops to discuss root causes and share process improvements across lines and departments.

    Customer service matters when something does go wrong. Our after-sales support doesn’t disappear after the invoice clears. We work with clients through formulation changes, new compliance targets, and shifts in manufacturing lines, whether for cost-saving, quality, or market expansion.

    Final Thoughts—Building Value in Every Batch

    Polysorbate 20 doesn’t just travel from our plant to a customer’s tank or blending line; it becomes a crucial part of finished goods used every day—household cleaners, baby wipes, eye drops, syrups, and shampoos. By taking pride in every step, from raw material sourcing to post-shipment questioning, one batch at a time, our team continues to shape the kind of consistency and trust that forward-looking companies need.

    For formulators wrestling with evolving consumer demands, global compliance, or legacy technical challenges, solutions rarely come from shortcuts. Our commitment remains anchored in real manufacturing, real technical detail, and ongoing partnership from purchase to final use. Whether sorting out cloud point puzzles or managing new audit requirements, our job doesn’t end when an order leaves the dock; it begins again, every batch, every time.